منابع مشابه
Detection of EPO doping and blood doping: the haematological module of the Athlete Biological Passport.
The increase of the body's capacity to transport oxygen is a prime target for doping athletes in all endurance sports. For this pupose, blood transfusions or erythropoiesis stimulating agents (ESA), such as erythropoietin, NESP, and CERA are used. As direct detection of such manipulations is difficult, biomarkers that are connected to the haematopoietic system (haemoglobin concentration, reticu...
متن کاملNo proof for augmented arterial oxygen content as only factor influencing exercise capacity after Epo doping.
TO THE EDITOR: In their paper, Lundby et al. (3) state that “the ergogenic effect of rHuEpo on V̇O2max can entirely be explained through the enhancement of the O2-carrying capacity of blood.” The main cause is assumed to be the increased hemoglobin concentration, since the blood volume was not raised and isovolemic hemodilution to control [Hb] decreased V̇O2max markedly. After carefully reading t...
متن کاملGASepo - a software solution for quantitative analysis of digital images in Epo doping control
A software has been developed that is aimed at quantitative analysis of images acquired by isoelectric focusing and double blotting procedures used for recombinant erythropoietin doping control. It represents a unified and easy-to-use tool for Epo doping experts in WADA accredited laboratories. It is based on image segmentation philosophy that enables identification of individual bands whose ch...
متن کاملEmerging EPO and EPO receptor regulators and signal transducers.
As essential mediators of red cell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5), ra...
متن کاملAnti-erythropoietin (EPO) receptor monoclonal antibodies distinguish EPO-dependent and EPO-independent erythroid progenitors in polycythemia vera.
Erythroid progenitor cells isolated from patients with polycythemia vera (PV) proliferate and differentiate in methylcellulose in the absence of exogenous erythropoietin (EPO). To investigate the potential role of the erythropoietin receptor (EPO-R) in the pathogenesis of PV, we cultured bone marrow-derived or peripheral blood-derived erythroid progenitors in the presence of neutralizing monocl...
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ژورنال
عنوان ژورنال: European Journal of Applied Physiology
سال: 2010
ISSN: 1439-6319,1439-6327
DOI: 10.1007/s00421-010-1417-7